Lethal Congenital Contracture Syndrome 1 (LCCS)

Lethal congenital contracture syndrome 1 (LCCS1), also called Multiple contracture syndrome, Finnish type,[1] is an autosomal recessive genetic disorder characterized by total immobility of a fetus, detectable at around the 13th week of pregnancy. LCCS1 invariably leads to prenatal death before the 32nd gestational week. LCCS1 is one of 40 Finnish heritage diseases. It was first described in 1985 and since then, approximately 70 cases have been diagnosed.[2]


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