Meckel-Gruber Syndrome

Meckel-Gruber syndrome is a rare, lethal ciliopathic genetic disorder, characterized by renal cystic dysplasiacentral nervous system malformations (occipital encephalocele), polydactyly (postaxial), hepatic developmental defects, and pulmonary hypoplasia due to oligohydramnios.[citation needed] Meckel–Gruber syndrome is named for Johann Meckel and Georg Gruber.[1][2][3]


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